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Green JB, Mottl AK, Bakris G, Heerspink HJL, Mann JFE, McGill JB, Nangaku M, Rossing P, Scott C, Gay A, et al

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Summary: Vitamin B12 treatment typically begins producing early haematological responses within 34 days, with neurological symptoms starting to improve within 12 weeks, though complete symptom resolution may require several weeks to months depending on deficiency severity and treatment route

The early week is biochemical priming melanogenic machinery is upregulating, but visible color change lags the molecular signal