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Younger subjects were euglycemic, but the elderly subjects had impaired glucose tolerance and higher concentrations of fasting glucose and glycated hemoglobin

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Oral peptide and protein delivery has not failed for lack of ingenuity or persistence, but because most peptides and proteins possess pharmacokinetic and pharmacodynamic properties fundamentally incompatible with the constraints of the oral route

GLP-1 RAs Long-acting GLP-1 receptor agonists Dulaglutide (Trulicity) Initial dose: 0.75 mg SubQ once weekly