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Side effects can be mitigated by using lower doses and combining TZD therapy with other medications (SGLT2i and GLP-1 RA) that promote weight loss and sodium excretion [199, 206]
Mechanism of Action The mechanism of action of Tirzepatide is defined by its function as a biased agonist at two distinct G-protein coupled receptors (GPCRs): the glucagon-like peptide-1 receptor (GLP-1R) and the glucose-dependent insulinotropic polypeptide receptor (GIPR)
Tirzepatide demonstrated approximately 5-fold lower affinity at the GLP-1 receptor compared to native GLP-1, and 20-fold lower potency in cellular signaling compared to semaglutide
10.1371/journal.pone.0050300 12
The estimated phentermine oral clearance (CL/F) is 8.79 L/h via population pharmacokinetic analysis
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