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If dehydration from GI side effects is the primary mechanism linking semaglutide to DVT, then real-world patients who self-manage these symptoms more aggressively might be better protected

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Malonyl-CoA inhibits the import of fatty acids into the mitochondria, thus reduced levels of malonyl-CoA lead to increased mitochondrial oxidation of long-chain fatty acids as described above

Of these 14 RYBELSUS-treated patients, 7 patients (0.2% of the total RYBELSUS-treated study population) developed antibodies that cross-reacted with native GLP-1

The findings were published in Cardiovascular Diabetology -- Endocrinology Reports