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Next, a separate research group sought to study the effects of CBD on the cognitive impairment, anxiety and psychotic symptoms associated with administration of cannabis primary psychoactive component, 9-THC

Although protein levels were not reported, in this study, mRNA levels for 5alpha-reductase and 3alpha-HSD were noted to be reduced in the hippocampus of these rats, which also had impaired performance on a hippocampal-dependent memory test and increased sensitivity to the anxiolytic effects of alphaxalone (303)