Any intervention that addresses these fundamental challenges holds promise for improving outcomes
TL;DR GLP-1 drugs such as semaglutide, tirzepatide, and liraglutide can help reduce appetite and body weight, but emerging research shows they may also increase the risk of protein, vitamin, and mineral deficiencies, especially when appetite drops sharply and food intake becomes too low or too limited
This is one of the reasons why I generally also recommend taking vitamin B6 in the P5P form, along with magnesium when taking most amino acids, to ensure proper utilization
Concurrently, disruptions in intracellular ATP and K + homeostasis elevate reactive oxygen species (ROS) levels, damage mitochondrial DNA (mtDNA), and promote the recruitment of NIMA-related kinase 7 (NEK7) to bind and activate the NLRP3 inflammasome
The longer acting GLP-1 receptor agonists are more effective than the shorter acting forms at reducing HbA 1c and fasting glucose levels, whereas the shorter acting forms are more effective at reducing postprandial glucose levels [3]