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Agladoglu SY, Cetnkaya S, Savas Erdeve S, Onder A, Kendrc HNP, Bas VN, Aycan Z

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It is downregulated in gastric and colorectal cancers but upregulated in lung adenocarcinoma and breast tumors compared to normal tissue ( In gastric and colorectal cancer, high CHAC2 expression leads to reduced glutathione, elevated intracellular Ca 2+ and increased ROS, resulting in inhibited tumor growth, proliferation and migration