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The liver has a large number of immune cells involved in the immune response and it has been found that macrophages are the largest proportion of immune cells (80-90%) in the human liver and they are closely related to the development and severity of MASLD (91)

Ozempic (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist

In addition, tirzepatide affects certain chemicals in the brain which in turn decreases appetite, increases energy expenditure, and prevents ectopic fat deposition (abnormal fat accumulation in body parts that normally contains small amounts of fat)

doi: 10.1016/j.cmet.2017.10.009 112 CannonBNedergaardJ