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Studies that have specifically examined renal safety markers found no toxicity signal

One investigation indicated that estrogen enhances C3 secretion in rat uterine epithelium, a phenomenon not replicated in the liver (82), suggesting that the effects of estrogen may be tissue-specific and cannot be generalized as universally activating the complement system

doi:10.1016/S0024-3205(00)00803-1 Min JH, Sarlus H, Harris RA (2024)

Once follicles are completely destroyed, no treatment can bring them back

Overall, the most successful approach to managing PCOS often includes both lifestyle improvements and, when appropriate, medications like semaglutide, all under the guidance of a healthcare provider