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Although peak inflammatory cytokine production (e.g., IL-1) may stem from localized MAPK/ERK dysregulation rather than direct endotoxin influx 174 , the cumulative impact of gutliver axis dysfunction in destabilizing cellular homeostasis remains an indispensable driver of the systemic pathogenesis of bovine laminitis

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Many women experience weight gain and fat accumulation in the waist region during their menopausal period [14]