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Interestingly, even heterozygous Bbs5 +/ mice, which displayed normal body composition and energy metabolism compared with WT controls (Supplemental Figure 1, KV), were resistant to leptin (Supplemental Figure 3, K, L, O, and P), suggesting that leptin resistance may serve as a potential biomarker even in individuals with a single Bbs gene mutation

doi: 10.1016/j.nano.2021.103716 182 ZhangZChenZXuY

Use amber glass vials or store in opaque containers inside the refrigerator

A single-dose i.v