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Addition of R-lipoic acid increases ATP synthesis and aortic blood flow during reoxygenation after hypoxia while S-lipoic acid had no effect on ATP synthesis and improved blood flow at only 10-fold the effective dose of R-lipoic

10.1038/s41419-024-07166-8 6 Alexandre-SantosB.AlvesR.MatsuuraC.Sepulveda-FragosoV.VelascoL

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Deficiencies can also affect our bodies energy resulting in fatigue, stress, reduction in physical stamina and tiredness, as well as disturbed sleep

On the high-dose sema-bima combination, patients lost exclusivley fat at 24 weeks and 90% fat mass at 48 weeks