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Reported nonclinical studies suggest that dual agonism of MC3R and MC4R offers increased efficacy without triggering side effects (25)

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Therefore, the severity of AD is classified from mild to severe according to various clinical scales such as the Eczema Area and Severity Index (EASI), the Investigator Global Evaluation (IGA), the Three Item Severity Score (TIS), and the SCORing Atopic Dermatitis (SCORAD) scales (7)

506 Evidence from fragile X syndrome mice has indicated that alterations in GABA-mediated synaptic transmission are present in the mice, suggesting that there is potential therapeutic benefit of GABA receptor agonism