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The study found that peripheral endothelial dysfunction independently correlated with future cardiovascular events, thus providing additional clinical significance for risk stratification in HFpEF patients

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Vitamin C augments lymphocyte glutathione in subjects with ascorbate deficiency. Am J Clin Nutr

Indeed, we observed similar circulating concentrations of sLRP-1, various pro-inflammatory cytokines including TNF-, and free cholesterol, which suggested that disruption of circulating ligand trafficking 64 , peripheral inflammation 65 , and cholesterol homeostasis 66 , respectively, did not occur at endpoint despite the marked effects on hepatic LRP-1 concentrations