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In an interview with Medscape Medical News , he said the evidence is not definitive, but more trials like TOGETHER-PsO are needed to show that concomitant use of GLP-1 RAs and primary antipsoriatic drugs are better than antipsoriatic drugs alone. In the multicenter TOGETHER-PsO trial, 276 patients with moderate-to-severe psoriasis and obesity or overweight were randomly assigned to treatment with the anti-interleukin-17A monoclonal antibody ixekizumab or to ixekizumab plus the dual GLP-1/GIP receptor agonist, tirzepatide

Today, Walgreens Weight Management offers GLP-1 agonist medications such as semaglutide (Wegovy oral pills & injectable pens), tirzepatide (Zepbound injectable KwikPens & vials), orforglipron (Foundayo pills), and liraglutide (Saxenda )

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Berberine likewise appears to be beneficial

The underlying concept - that gut microbiome composition and function can influence metabolism - is supported by published research