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The loss of a major hepatic form of GST, which represents over 3% of total soluble protein (Fountoulakis et al ., 2000), would have been expected to predispose the animals to hepa-totoxicity through a reduction in the glutathione conju-gation of NAPQI (Coles et al ., 1988)
Hadley MB, Henderson SB, Brauer M, Vedanthan R
Healthcare professionals should counsel patients about this possibility and provide symptomatic management strategies, including dietary modifications, antiemetic therapy if appropriate, and adequate hydration