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Nrf2 is a candidate gene

Furthermore, pathway analysis of patient groups revealed four transcriptome groups

These reactions are usually catalyzed by a family of isoenzymes called glutathione S -transferases [6] (for a review)

Reduced GSH levels shown by decreases in this ratioboth in the plasma and intracellularlyreflect intracellular shifts in oxidative burden and are indicative of immune dysfunction and progression of various disease states such as infection, sepsis, and age-related immune system decline (Rossi et al., 2006

Pro-caspase-1 is recruited to the complex upon inflammasome assembly and undergoes autoproteolytic cleavage to generate active caspase-1