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For most healthy adults, digestive enzyme supplements appear to be well tolerated in the short term, especially when taken as directed.41 Clinical trials of multi-enzyme blends for functional dyspepsia a common cause of post-meal fullness and upper-abdominal discomfort have found significant symptom improvements with no increase in adverse events compared with placebo.7 8 A broader review of digestive enzyme therapy in GI diseases also concludes that these products generally have a favorable safety profile when used appropriately, while emphasizing that high-quality data on OTC digestive enzyme blends is still limited.14 21 Single-enzyme products such as lactase, alpha-galactosidase, and XI likewise show good tolerability in randomized trials, with side-effect rates similar to placebo and only occasional mild GI symptoms like gas or cramping.2 3 4 11 40 That said, not every formula is the same

Ghandi S, Aflatoonian A, Tabibnejad N, Moghaddam MHS (2011) The effects of metformin or orlistat on obese women with polycystic ovary syndrome: a prospective randomized open-label study

Each ingredient in this pre-workout supplement was chosen based on scientific research and quality characteristics