Nature 491:364373 Schulte ML, Fu A, Zhao P et al (2018) Pharmacological blockade of ASCT2-dependent glutamine transport leads to anti-tumor efficacy in preclinical models
Two recent studies present additional mechanisms underlying cystine starvation-induced ferroptosis apart from impaired GSH synthesis
FIGURE 9 Discussion Glutathione peroxidase is a crucial antioxidant enzyme that participate in restraining the harmful accumulation of intracellular hydrogen peroxide and is more effective than catalase at eliminating intracellular peroxides under various physiological conditions ( In the present study, the role of GPX1 in SGNs treated with peroxynitrite was explored via using ebselen and GPX1 deficient mice
The most appropriate approach may range from a few targeted biomarkers to an advanced nutrient panel, depending on diet, symptoms, medical history, medications, absorption risks, and previous results
Zhou J, Nie RC, Yin YX, Cai XX, Xie D, Cai MY (2022) Protective effect of natural antioxidants on reducing cisplatin-induced nephrotoxicity