Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin
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& Lim, J
The inflammation-modulatory effects of hBMSC treatment included a significant increase in the gene expression of IL-10 and its receptor in ovarian tissues, elevated serum levels of IL-10, IFN-, and tissue inhibitor of metalloproteinase-2, and a decrease in the gene expression of pro-inflammatory markers such as IL-6, IL-1, CCL2, and CD11c in the adipose tissue of PCOS mice [135]
Following PRISMA methodology, the current review addresses the use of natural antioxidants, such as epigallocatechin gallate (EGCG), melatonin and resveratrol (RESV), as well as other classical antioxidants (vitamin C and E) during the prenatal period as treatment of the above-mentioned complications