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examined the effect of liraglutide on NAFLD in a high-fat diet (HFD) SpragueDawley (SD) rat model for 4 weeks and reported improvement in hepatic steatosis, lobular inflammation, and ballooning

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There is a large set of requirements for barrier models: strong barrier function, the presence of a wide range of transporters and receptors, regulation of immune cell trafficking, mimicking a complex interaction of several types of cells, as well as, a dynamic balance between the cells

For instance, it can affect levels of hormones like ghrelin (often called the hunger hormone) and leptin (the satiety hormone)