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The STEP clinical trials, which tested semaglutide at multiple dose levels, showed that participants lost an average of 15% of their baseline body weight over 68 weekstranslating to roughly 0.25 to 0.75 pounds weekly on average, though results cluster around higher losses during active treatment phases

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A study in 73 healthy adolescents using 24-hour GH sampling found mean integrated GH concentrations of 3.8 ng/mL in mid-puberty compared with 1.1 ng/mL in young adults, a 3.5-fold difference [5]