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Dysbiosis-induced increased intestinal permeability allows the translocation of bacterial endotoxins, notably LPS, into the systemic circulation, triggering inflammatory cascades that compromise thyroid tissue integrity and hormone synthesis

By increasing your bodys overall energy production, less pure muscular energy is required

This leads to DNA damage, DNA copying errors, and eventually, aging

Diagnostic criteria varied across studiessome applied Rome IV/III criteria, others used ICD-based diagnoses, validated rating scales (PHQ-9, HAMD), or self-report

Its a key player in your bodys energy production, which is why you might feel sluggish when your levels are low