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At the same time, GLP1 suppresses gallbladder motility

The most common experiences are nausea (particularly during dose escalation), vomiting, diarrhoea or constipation, reduced appetite and early satiety, and fatigue during the adjustment period

When activated, they slow gastric emptying (making you feel full longer), increase insulin secretion, reduce glucagon release, and send satiety signals to the hypothalamus

Shortening below 4 weeks consistently increases adverse event rates without improving outcomes

Brown, MD, PhD Professor of Medicine and Epidemiology Division of Endocrinology, Diabetes, & Metabolism Johns Hopkins University Baltimore, Maryland, US