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[DOI] [PMC free article] [PubMed] [Google Scholar] 225.Liu J, et al
[3] Combining Ozempic with DPP-4 inhibitors is generally not recommended in UK practice
Glucagon receptor activation: Increases hepatic glucose output (relevant in fasted states), stimulates lipolysis in adipose tissue, and raises basal metabolic rate through thermogenic mechanisms
In addition, we showed that GLP-1stimulated insulin secretion is not impaired in islets derived from whole-body Barr1-KO mice (Supplemental Figure 10)
References: Baggio LL, Drucker DJ (2007): Biology of incretins: GLP-1 and GIP
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