Primary care physicians will likely need education and training focused on this new class of medications, given a shortage of endocrinologists and obesity medicine specialists. Lee and colleagues noted there were study limitations, such as a lack of data on prescription indication, including whether it was used off-label. However, the increase in dispensing of injectable semaglutide for weight management suggests increasing use for this indication, they wrote
Mounjaro is typically administered once a week on the same day
Acute studies generally show that activating ARC AgRP/NPY neurons increases food intake, while activating ARC POMC neurons suppresses food intake with the opposite profile seen with their respective inhibition [134,135,136,137,138]
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Each IV therapy protocol is customised after clinical evaluation to ensure safety and relevance for the patient