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When consuming the same amount of folic acid, people with the MTHFR 677 TT genotype (two copies of T, one copy from each parent) have on average 16% less folate in their blood than people with the MTHFR 677 CC genotype (two copies of C)

B12 absorption declines with age (4)

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NICE guidelines recommend hydroxocobalamin 1 mg intramuscularly three times weekly for 2 weeks (without neurological involvement) or on alternate days until no further improvement (with neurological symptoms)