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As for safety, tolerable upper intake levels (known as ULs) are set for vitamins and minerals when evidence is sufficient

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Kojic acid has been used for decades in topical skincare, particularly in creams, soaps, and serums

-glutamyltranspeptidase cleaves glutathione at the unique -glutamyl bond to form free glutamate and the dipeptide Cys-Gly, which is degraded to Cys and Gly for transport in to cells via amino acid transporters

The most frequently reported adverse effects are gastrointestinal in nature and are related to the drug's mechanism of action, which slows gastric emptying and enhances satiety