They may also be prescribed for those with a BMI of 27 or higher who have obesity-related conditions such as type 2 diabetes, high blood pressure, high cholesterol, or sleep apnea
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Greater variability was seen in Glp2r, with 14 of 77 examined species displaying 5 or more amino acid substations in the shared ligand interacting sites, while only 1 and 3 species, for Gcgr and Glp1r, respectively, showed this amount of change ( Supplementary Table 13 )
Reasons for low levels of initiation and long-term use of AOMs may include reluctance of public health and medical organizations to recognize obesity as a disease, lack of reimbursement, provider inexperience, and misperceptions about the efficacy and safety of available treatments
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