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The positive charge because of Dioleoyl-3-trimethylammonium propane (DOTAP), on the surface of the liposome, improved its affinity for the anionic skin membrane resulting in enhanced efficiency in a psoriatic plaque model induced by imiquimod (IMQ) [324]
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Palmer CD, Scallan CD, Kraemer Tardif LD, Kachura MA, Rappaport AR, Koralek DO, et al