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For example, taking very high doses of vitamin B6 can lead to potentially irreversible nerve damage over time, while taking large amounts of niacin typically in excess of 2 grams per day can cause liver damage ( Fat-soluble vitamins Unlike water-soluble vitamins, fat-soluble vitamins do not dissolve in water and are easily stored in your bodys tissues ( There are four fat-soluble vitamins: Vitamin A Vitamin D Vitamin E Vitamin K Given that fat-soluble vitamins can accumulate in the body, these nutrients are more likely to lead to toxicity than water-soluble vitamins

doi: 10.5650/jos.ess14281

C-terminal amidation, as seen in Nle-Tyr-Ile-His-NH, also provided a more modest increase in stability

Nachemson A, Elfstrom G

Any temperature excursion above 25C (room temperature) for more than 24 hours causes irreversible denaturation