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These prespecified analyses considered factors such as age, hypertension, heart failure, eGFR, proteinuria, new users after the index day, enrollee after 2006 and concurrent usage of other medications for glycemic control, and renin-angiotensin-aldosterone system (RAAS) blockers

Strategies to Mitigate GI Side Effects Gradual dose escalation: Slowly increasing the dose over several weeks reduces the likelihood of severe nausea and vomiting

Microdosing GLP-1s: A Doctors Guide to Gentle, Effective Metabolic Reset GLP-1 medicationslike semaglutide (Ozempic/Wegovy) and tirzepatide (Mounjaro/Zepbound)have changed the way we treat metabolic disorders, insulin resistance, PCOS, and even support hormonal balance through perimenopause and beyond

doi: 10.1007/s11883-025-01350-7

Current NICE guidance for alcohol use disorder (CG115) recommends a stepped-care approach beginning with brief interventions and psychological therapies, progressing to specialist assessment and treatment for moderate to severe AUD