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I., Giukova A

1005 Zheng, X

Lixisenatide and exenatide used in ELIXA and EXSCEL trials are short-acting GLP-1RAs that are structurally similar to exendin-4, a peptide found in the saliva of the Gila monster Heloderma suspectum

Three studies (35 patients) showed a reduction in hypoglycaemic events and one case series showed a mix of 12 episodes (47% n = 7), complete resolution (40% n = 6) and no change (13% n = 2), however it is important to note that of the initially recruited 25 patients in this case series only 15 responded [18, 19, 21, 28]

It needs long-term commitment, medical insight, and lifestyle adjustments