One way of screening for sensitivity to primaquine is based on the observation that the glutathione concentration of erythrocytes from sensitive subjects is somewhat lower than that of control subjects, and falls considerably on incubation with acetylphenylhydrazine
Reduced-frequency alternatives include 2 to 3 mg three times per week or 2 mg every other day, producing similar weekly exposure with fewer injections
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Rather than extreme restriction, I recommend a modest calorie deficit paired with high-volume, nutrient-dense foods like vegetables, fruits and lean proteins, she notes
Apperloo EM, Neuen BL, Fletcher RA, et al