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Pregnancy : Many women get dark patches on their face during pregnancy

10.1073/pnas.0903015106 29

Retinol-binding protein 4 and its membrane receptor STRA6 control adipogenesis by regulating cellular retinoid homeostasis and retinoic acid receptor activity

Seek same-day care if: The rash involves your eyelids, eyes, or the area around your mouth Redness is spreading rapidly beyond the original rash boundaries with warmth and swelling, suggesting bacterial infection Blisters are producing pus or cloudy discharge Fever develops Significant facial or limb swelling occurs The rash covers a large portion of your body surface Prescription-strength oral corticosteroids are the most effective treatment for severe, spreading reactions

Handle reconstituted solution with care and keep cold at all times during use