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Serotonin plays a critical role in mood regulation, sleep patterns, and appetite control, and its dysregulation is strongly linked to depression and anxiety [86]

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Reports across the 1980s described DSIP modulation of responses to morphine, amphetamine and barbiturates in rodents, with a profile generally interpreted as opioid-system modulation rather than direct opioid-receptor binding (Graf & Kastin, 1984)