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Under high glucose conditions, in 661W cells and photoreceptor cells of diabetic mice, the expression of GPX4 and SLC7A11 is downregulated, while the expression of ACSL4, FTH1, and NCOA4 is upregulated

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In addition, increasing TFAM levels enhanced mitochondrial DNA transcription and replication, aiding in the recovery of mitochondrial function, while boosting GPX4 levels directly reduced LPO buildup, thereby preventing ferroptosis