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Weeks 1 through 4: the quiet surprise Most researchers describe the first month as a revelation
The first consists in the study of the expression of single candidate genes already known to be target of redox-regulation, such as cjun43 and NF-B.44 However, since it has been shown that the biological response due to oxidative stress is mediated by the modification of a complex array of genes,45 the study of single candidate genes may not be adequate to solve the complexity of oxidative-stress-based liver pathologies
Dickerson J, Bressler R, Christian CD
The same goes for suggested risks, some of which make clear sense (eg, more nausea and vomiting) and have been seen in trials, but many others have not, and findings could simply reflect unmeasured confounding. He added: Fortunately, large scale randomised trials with GLP-1RA-based therapies that yield greater weight loss are ongoing and several will report out in the next 1-4 years
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