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The dose definitions followed original RCT classifications [10,11,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50]

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4 Currently, the clinical management of SAP primarily involves supportive and symptomatic treatment, including fluid resuscitation, pain control, antibiotic therapy, enteral or parenteral nutrition, and preventive interventions targeting the underlying cause of AP

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In the United States, melatonin is sold as a dietary supplement, which eliminates the need for these products to be approved by the Food and Drug Administration (FDA)