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Symptoms such as fatigue, weakness, nausea, vomiting, and swelling of the hands and feet are increasingly probable at this stage, but some patients have no symptoms whatsoever

Based on this, one may hypothesize that the zonated pericentral damage of OTA is due to lower expression of albumin in the pericentral hepatocytes as evidenced by immunostaining in the present study

Cui, S.-Y

Topical treatments and oral supplements require consistent use over several months for gradual brightening

6 Northern blot analysis of poly(A) + RNA from one of these previous patients (10665), used as a positive control, and our new patients with carnitine deficiency is shown in Figure 4