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If the primary outcome showed superiority, secondary outcomes were tested in a pre-specified order to control the type I errors Total eGFR slope (the annual rate of change in eGFR from randomization to the end of the trial) Major cardiovascular events (a composite of nonfatal MI, nonfatal stroke, or death from CV causes) Death from any cause The other supportive secondary outcomes are shown in the figure below

Month 6 to 12 and Beyond: Long-Term Outcomes Continued treatment plus lifestyle measures commonly leads to larger losses between six and twelve months

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Managing Side Effects and Workout Performance Nausea is the most commonly reported side effect of semaglutide, affecting roughly 2030% of users in clinical trials