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However, many patients and health care providers prefer to avoid adding more medicines when possible

Summary Dizziness is a common semaglutide side effect, with a 2025 real-world cohort reporting 15% of patients experienced dizziness after starting treatment, and many episodes occur in the evening or persist after gastrointestinal symptoms ease

Moreover, liraglutide 3.0 mg (i.e., the dose level approved for weight management for this GLP-1 RA) in combination with lifestyle intervention markedly reduced the presence of visceral fat over a period of 40 weeks ( The reductions in ROS and systemic inflammation, in combination with improvements in the other cardiometabolic parameters, are also thought to mediate the substantiated but so far formally unconfirmed kidney-protective effects of GLP-1 RAs, which may also directly or indirectly carry a HF-related benefit, considering that CKD is a prominent risk factor for HF (von Scholten et al., 2022)