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doi: 10.3390/antiox3040830 226 SirajMAShilpiJAHossainMGUddinSJIslamMKJahanIAet al

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A comprehensive microbiome analysis involving 480 participants across CKD stages 15 and healthy controls revealed a progressive decline in the abundance of Lactobacillus johnsonii , correlating with worsening renal function ( Furthermore, disturbances in gut-derived metabolites, particularly the accumulation of uremic toxins alongside the depletion of beneficial metabolites, represent another critical driver of CKD progression