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Nrf2 belongs to the CNC protein family, including NF-E2 p45, Nrf1, Nrf3, Bach1, and Bach2 (Motohashi et al., 2002)
This is known in functional medicine as the "NAC Paradox." While NAC provides the raw cysteine needed for the body to build its own glutathione, clinical observations indicate that NAC can act as a direct histamine liberator in sensitive individuals
However, beyond the primary endpoint, this study then became an open-label trial up to week 52
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