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As responsible citizens, it is time we recognize the gravity of clinical research

Ciccarese C, Brunelli M, Montironi R, Fiorentino M, Iacovelli R, Heng D, et al

Current limitations include the complexity of the mechanisms of action, which makes it difficult to identify predictive biomarkers of response, the lack of detailed pharmacokinetic data for synthetic TB-500, and the difficulty of translating effective doses from animal models to humans

To minimize confounding factors related to the estrous cycle and ensure experimental consistency, we used only male mice in this study

Once the Trp residue is oxidized, the peptide no longer matches its intended sequence and loses biological activity