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Monitoring during treatment should be individualised according to local specialist weight management service protocols and the patient's IBD team recommendations: Initial phase : Regular contact during dose escalation (first 5 weeks) to assess tolerability and gastrointestinal symptoms

A single overnight period at room temperature, roughly 8 to 12 hours, will reduce potency by an estimated 2 to 5 percent depending on the ambient temperature

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Many natural and synthetic substrates used by laccases have an ortho -methoxy substituent on the phenol, an electron-donating moiety that facilitates oxidation 29

Cloudiness or particulate matter in the solution indicates aggregation