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The co-culture of human primary hepatocytes and endothelial cells can support hepatocytes to maintain their phenotypic morphology, improve their specific functions and form capillary-like structures, which is more conducive to simulate the in vivo environment and studying the pathological mechanisms of fatty liver disease (208)

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A recent observational study looked at adults with chronic insomnia who took melatonin for at least a year compared to adults who didn't take it and noted an increased risk of heart failure or death among those who took melatonin versus those that didn't

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