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& Sevov, C

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As a result, more comprehensive mechanistic and pharmacological studies are needed to determine whether these systems are viable candidates for metallodrug development

Since mitochondrial failure appears to be a major factor in the development of target organ damage linked to HTN, mitochondria have emerged as a possible target for treatment

After completion, as monitored by UPLC and ESI-LCMS, the reaction mixture was diluted with buffer A, filtered and purified directly by preparative RP-HPLC, eluting with a linear gradient (see the Peptide cleavage and purification section)