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4 A 2025 study in Metabolic Syndrome and Related Disorders found that postmenopausal women taking low-dose semaglutide lost fat at a rate comparable to premenopausal women, despite having a higher baseline weight and fat mass

That is enough to produce meaningful GLP-1 and GIP receptor stimulation that stacks with the retatrutide you are introducing

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A., Fauth, C., Bergheim, C., Meierhofer, D., Radmayr, D., Zschocke, J., Koch, J., and Sperl, W