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HDL is required to remove excess cholesterol from the plasma membrane of platelets for proper function, and platelets isolated from mice lacking SR-BI to mediate cholesterol efflux to HDL were found to be more susceptible to activation (828,829)

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It has been concluded that the transcriptomic changes induced by -blockers are closely linked to alterations in MEF2 expression, suggesting that the responsiveness of MEF2 to -blockade is context-dependent and may vary with treatment duration and intensity (Tobin et al., 2017)

Individuals with certain genetic profiles may experience faster or more severe hunger rebound after stopping tirzepatide